| Game Name |
Publisher |
Play Mode |
Region |
| Are You Smarter Than a 5th Grader? Game Time | THQ, Inc. | Cooperative; Multiplayer | |
| The Chronicles of Narnia: Prince Caspian | Disney Interactive Studios | Single Player | |
| Eco-Creatures: Save the Forest | Interchannel | Multiplayer | |
| Digimon World Dusk | Namco Bandai Games | Multiplayer | |
| Cake Mania 2: Jill's Next Adventure! | Majesco | Single Player | |
| Mega Man Star Force: Dragon | Capcom | Single Player | |
| Draglade | Atlus | Multiplayer | |
| Pirates of the Caribbean: Dead Man's Chest | Buena Vista Games | Multiplayer | |
| Dr. Seuss: How the Grinch Stole Christmas! | DSI Games | Multiplayer | |
| Major League Baseball 2K10 | 2K Sports | Multiplayer | |
| Jake Hunter: Detective Story: Memories of the Past | Aksys Games Localization, Inc. | Single Player | |
| Dungeon Explorer: Warriors of Ancient Arts | Hudson Soft | Multiplayer | |
| Point Blank DS | Namco Bandai | Multiplayer | |
| Shrek's Carnival Craze: Party Games | Activision | Multiplayer | |
| Assassin's Creed: Altair's Chronicles | Ubisoft | Single Player | |
| Naruto: Path of the Ninja | Tomy Corporation | Single Player | |
| Blades of Thunder II | Summitsoft Entertainment | Multiplayer | |
| Brain Buster Puzzle Pak | Agetec | Single Player | |
| Harry Potter and the Order of the Phoenix | Electronic Arts | Single Player | |
| Cake Mania 3 | Majesco | Single Player | |
| ATV: Quad Frenzy | Majesco | Multiplayer | |
| Harvest Moon DS: Sunshine Islands | Natsume | Single Player | |
| F24: Stealth Fighter | | Multiplayer | |
| Anno 1701: Dawn of Discovery | Ubisoft | Multiplayer | |
| Ford Racing 3 | Destination Software, Inc. | Multiplayer | |
| Di-Gata Defenders | The Game Factory | Single Player | |
| Godzilla Unleashed: Double Smash | Atari SA | Multiplayer | |
| MySims Kingdom | Electronic Arts | Multiplayer | |
| Legend of Kay | Dream Catcher | Single Player | |
| Justice League Heroes | Warner Bros. Interactive Entertainment Inc. | Single Player | |
| 2006 FIFA World Cup: Germany 2006 | Electronic Arts | | |
| Rock Blast | UFO Interactive Games, Inc. | Single Player | |
| CSI: Crime Scene Investigation: Dark Motives | Ubisoft | Single Player | |
| Operation: Vietnam | Majesco Entertainment | Single Player | |
| Elements of Destruction | THQ | Multiplayer | |
| High School Musical 3: Senior Year | | Multiplayer | |
| Power Rangers: Super Legends | Disney Interactive Studios | Multiplayer | |
| Mazes of Fate DS | Graffiti Entertainment | Single Player | |
| Barbie and the Three Musketeers | Activision | Single Player | |
| Escape the Museum | GameMill Entertainment | Single Player | |
| Family Feud: 2010 Edition | | Single Player | |
| My Make-Up | | Multiplayer | |
| GhostBusters: The Video Game | Atari | Single Player | |
| Imagine: Interior Designer | | Multiplayer | |
| Retro Game Challenge | Namco | Single Player | |
| Nostalgia | Ignition Entertainment | Single Player | |
| Ice Age 2: The Meltdown | Sierra Entertainment | Single Player | |
| Shin Megami Tensei: Devil Survivor | Atlus | Single Player | |
| Ridge Racer DS | Namco Hometek Inc. | Multiplayer | |
| Rhapsody: A Musical Adventure | Atlus | Single Player | |
| Dogz | Ubisoft | Multiplayer | |
| My DoItAll | Tomy Corporation | Multiplayer | |
| Disney Fairies: Tinker Bell and the Lost Treasure | Disney Interactive Studios | Single Player | |
| Littlest Pet Shop: Spring | Electronic Arts | Multiplayer | |
| Incredibles, The: Rise of the Underminer | THQ | Single Player | |
| Journey to the Center of the Earth | THQ | Multiplayer | |
| Balls of Fury | Destination Software, Inc. (DSI) | Multiplayer | |
| Jewel Master: Cradle of Egypt 2 | Rising Star Games | Multiplayer | |
| Deep Labyrinth | Atlus | Single Player | |
| C.O.P.: The Recruit | Ubisoft | Single Player | |
| Labyrinth | UFO Interactive | Multiplayer | |
| Bratz Ponyz 2 | | Multiplayer | |
| Barbie as the Island Princess | Activision | Multiplayer | |
| Super Scribblenauts | Warner Bros. Interactive | Single Player | |
| Burnout Legends | Electronic Arts | Multiplayer | |
| Bratz: Forever Diamondz | THQ | Single Player | |
| Imagine: Cheerleader | Ubisoft, Inc. | Multiplayer | |
| Flushed Away | D3 Publisher Inc. | Single Player | |
| Mini Ninjas | | Multiplayer | |
| Mega Man Star Force: Pegasus | Capcom | Single Player | |
| Bella Sara | Codemasters | Multiplayer | |
| Hands On! Tangrams | Storm City Games | Multiplayer | |
| Dragon Quest 9: Sentinels of the Starry Skies | Square Enix | Multiplayer | |
| Dinosaur King | Sega | Multiplayer | |
| The Bigs 2 | 2K Sports | Multiplayer | |
| Monster Lab | Eidos | Multiplayer | |
| Original Frisbee Disc Sports: Ultimate & Golf | Sega | Multiplayer | |
| Little League World Series Baseball 2008 | Activision | Multiplayer | |
| Phantasy Star 0 | Sega | Multiplayer | |
| Hell's Kitchen: The Game | Ubisoft | Multiplayer | |
| Spider-Man: Shattered Dimensions | Activision | Multiplayer | |
| Plants vs. Zombies | PopCap Games | Multiplayer | |
| Drake & Josh: Talent Showdown | | Multiplayer | |
| Imagine: Teacher | | Multiplayer | |
| Asphalt: Urban GT 2 | Gameloft | Multiplayer | |
| FIFA Soccer 09 | EA Sports | Multiplayer | |
| Reversal Challenge | | Multiplayer | |
| Lovely Lisa | Takara Tomy | Multiplayer | |
| Elf Bowling 1 & 2 | | Multiplayer | |
| Mega Man Battle Network 5: Double Team DS | Capcom | Single Player | |
| Alvin and the Chipmunks: The Squeakquel | Majesco Entertainment | Single Player | |
| My Little Pony: Pinkie Pie's Party | THQ | Multiplayer | |
| Cheer We Go | Konami | Multiplayer | |
| Nanostray 2 | Majesco | Cooperative; Multiplayer | |
| FIFA Soccer 07 | EA Sports | Multiplayer | |
| Guinness World Records: The Videogame | | Multiplayer | |
| Dreamer Series: Top Model | DreamCatcher Interactive | Multiplayer | |
| Final Fantasy Crystal Chronicles: Ring of Fates | Square Enix | Multiplayer | |
| New Carnival Games | | Multiplayer | |
| Phoenix Wright: Ace Attorney: Justice for All | Capcom | Single Player | |
| Jumble Madness | | Multiplayer | |
| Rooms: The Main Building | Hudson Entertainment | Single Player | |
| Nervous Brickdown | Eidos Interactive | Single Player | |
| Hamsterz Life | Ubisoft | Single Player | |
| Lunar Knights | Konami | Multiplayer | |
| Mystery P.I. Portrait of a Thief | PopCap Games | Multiplayer | |
| My Horse & Me | Atari | Multiplayer | |
| Marvel Super Hero Squad: The Infinity Gauntlet | THQ | Multiplayer | |
| Naruto: Path of the Ninja 2 | Tomy Corporation | Single Player | |
| Iron Man 2 | Sega | Single Player | |
| Kirby Super Star Ultra | Nintendo | Cooperative; Multiplayer | |
| Code Lyoko: The Fall of X.A.N.A | The Game Factory | Multiplayer | |
| Fossil Fighters | Nintendo | Multiplayer | |
| Dream Chronicles | | Multiplayer | |
| Code Lyoko | The Game Factory | Single Player | |
| Nacho Libre | Atari | Multiplayer | |
| Bookworm | PopCap Games, Inc. | Multiplayer | |
| Monster Bomber | | Multiplayer | |
| Spider-Man: Web of Shadows | Activision | Single Player | |
| C.O.R.E. | Graffiti Entertainment | Multiplayer | |
| Brain Challenge | Ubisoft | Single Player | |
| Imagine: Babyz Fashion | Ubisoft | Single Player | |
| Scribblenauts | Warner Bros. Interactive | Single Player | |
| Tigre, El: The Adventures of Manny Rivera | THQ | Multiplayer | |
| Aliens in the Attic | PlayLogic | Single Player | |
| Ice Age: Dawn of the Dinosaurs | Activision | Multiplayer | |
| Apollo Justice: Ace Attorney | Capcom | Single Player | |
| Diddy Kong Racing DS | Nintendo | Multiplayer | |
| Ben 10: Alien Force | D3Publisher | Single Player | |
| Napoleon Dynamite: The Game | Crave | Multiplayer | |
| Littlest Pet Shop: Beach Friends | | Multiplayer | |
| The Humans: Meet the Ancestors! | Deep Silver | Multiplayer | |
| Barnyard Blast: Swine of the Night | DSI Games | Single Player | |
| Izuna: Legend of the Unemployed Ninja | Atlus | Single Player | |
| Chronicles of Mystery: Curse of the Ancient Temple | City Interactive | Multiplayer | |
| The Cheetah Girls: Passport to Stardom | | Multiplayer | |
| Bratz 4 Real | THQ | Multiplayer | |
| Avatar: The Last Airbender | THQ | Single Player | |
| I Spy: Fun House | Scholastic | Single Player | |
| FIFA Street 2 | EA Sports BIG | Multiplayer | |
| Super Princess Peach | Nintendo | Single Player | |
| Americas Next Top Model | dtp Young Entertainment AG | | |
| The Incredible Hulk | Sega | Multiplayer | |
| Mushroom Men: Rise of the Fungi | Gamecock | Single Player | |
| Ben 10: Protector of Earth | D3 Publisher | Single Player | |
| Mega Man Star Force 3: Red Joker | Capcom | Single Player | |
| LEGO Battles: Ninjago | Warner Bros | Single Player | |
| Animal Paradise: Wild | Zoo Games | Multiplayer | |
| Deal or No Deal | Mindscape | Single Player | |
| Mega Man ZX: Advent | Capcom | Cooperative; Multiplayer | |
| The Legend of Zelda: Spirit Tracks | Nintendo | Multiplayer | |
| Kung Fu Panda: Legendary Warriors | Activision | Single Player | |
| Are You Smarter Than a 5th Grader? Make the Grade | THQ | Cooperative; Multiplayer | |
| Bratz: Super Babyz | | Multiplayer | |
| The Bee Game | Midway Games | Multiplayer | |
| Etrian Odyssey | Atlus | Single Player | |
| Micro Machines V4 | Codemasters | Multiplayer | |
| The Spiderwick Chronicles | Sierra | Single Player | |
| Cate West: The Vanishing Files | Destineer Games | Single Player | |
| Cookie & Cream | Agetec | Multiplayer | |
| Ratatouille: Food Frenzy | THQ | Multiplayer | |
| Devilish | UFO Interactive | Single Player | |
| Harvest Moon DS | Natsume / Marvelous Entertainment | Single Player | |
| Bubble Bobble Revolution | Codemasters | Multiplayer | |
| Nanostray | THQ | Multiplayer | |
| Great Empires: Rome | Valcon Games | Multiplayer | |
| Pokemon Mystery Dungeon: Blue Rescue Team | Nintendo | Single Player | |
| Rain Drops | | Multiplayer | |
| Interactive Storybook DS: Series 3 | | Multiplayer | |
| MLB Power Pros 2008 | 2K Sports | Multiplayer | |
| Marvel Nemesis: Rise of the Imperfects | Electronic Arts | Multiplayer | |
| Fosters Home For Imaginary Friends: Imagination Invaders | | Multiplayer | |
| Looney Tunes: Cartoon Conductor | Eidos Interactive | Single Player | |
| MechAssault: Phantom War | Majesco Entertainment | Multiplayer | |
| George of the Jungle and the Search for the Secret | Ignition Entertainment | Multiplayer | |
| Chaotic: Shadow Warriors | Activision Publishing, Inc. | Multiplayer | |
| SpongeBob SquarePants featuring Nicktoons: Globs of Doom | Play THQ | Multiplayer | |
| Reader Rabbit: Kindergarten | The Learning Company | Multiplayer | |
| Blue Dragon Plus | Feel Plus | Single Player | |
| FIFA Street 3 | EA Sports BIG | Multiplayer | |
| Honeycomb Beat | Hudson | Multiplayer | |
| Madden NFL 08 | EA Sports | Multiplayer | |
| Lord of the Rings, The: Conquest | Electronic Arts | Multiplayer | |
| G-Force | Disney Interactive | Multiplayer | |
| High School Musical: Makin' the Cut! | | Multiplayer | |
| Nancy Drew: The Hidden Staircase | | Multiplayer | |
| Luminous Arc | Atlus | Multiplayer | |
| LEGO Batman: The Videogame | Warner Bros Interactive | Multiplayer | |
| Castlevania: Order of Ecclesia | Konami | Multiplayer | |
| Bolt | Disney Interactive | Multiplayer | |
| MX vs. ATV: Untamed | THQ | Multiplayer | |
| My Pet Shop | | Multiplayer | |
| Dokapon Journey | Atlus | Multiplayer | |
| Harry Potter and the Goblet of Fire | Electronic Arts | Single Player | |
| My Fun Facts Coach: Facts for Your Daily Life | | Multiplayer | |
| Death Jr. and the Science Fair of Doom | Konami | Multiplayer | |
| Pirates of the Caribbean: At World's End | Disney | Multiplayer | |
| Disney Fairies: Tinker Bell | Disney Interactive Studios | Multiplayer | |
| Monster Jam: Urban Assault | Activision | Multiplayer | |
| Catz | Ubisoft | Single Player | |
| Juiced 2: Hot Import Nights | THQ | Multiplayer | |
| Final Fantasy Crystal Chronicles: Echoes of Time | Square Enix | Multiplayer | |
| Jane's Hotel | | Multiplayer | |
| Big Mutha Truckers | Empire Interactive | Multiplayer | |
| The Legendary Starfy | Nintendo | Single Player | |
| Princess Natasha: Student, Secret Agent, Princess | DSI Games | Multiplayer | |
| Blue Dragon: Awakened Shadow | D3 Publisher | Multiplayer | |
| Drawn to Life: The Next Chapter | THQ | Single Player | |
| Igor: The Game | South Peak | Multiplayer | |
| Club Penguin: Elite Penguin Force | Disney Interactive Studios | Multiplayer | |
| Dragon Quest 6: Realms of Revelation | Square Enix | Single Player | |
| Little Red Riding Hood's Zombie BBQ | Destineer | Single Player | |
| 4 Game Pack!: Battleship Connect Four Sorry! Trouble | Destination Software, Inc. | Multiplayer | |
| Dragonology | Codemasters | Multiplayer | |
| Backyard Football | Atari, Inc. | Multiplayer | |
| LEGO Rock Band | Warner Bros. Interactive | Single Player | |
| Overlord Minions | Codemasters | Multiplayer | |
| Petz: Catz 2 | Ubisoft | Single Player | |
| Glory of Heracles | Nintendo | Single Player | |
| Marvel: Ultimate Alliance 2 | Activision | Multiplayer | |
| Digimon World Dawn | Namco Bandai Games | Multiplayer | |
| Imagine: Movie Star | | Multiplayer | |
| My Baby Girl | SouthPeak Interactive Ltd | Multiplayer | |
| Lost in Blue 3 | Konami | Multiplayer | |
| Cartoon Network Racing | Game Factory | Multiplayer | |
| Need for Speed: ProStreet | Electronic Arts | Multiplayer | |
| My Frogger Toy Trials | Konami | Single Player | |
| The Cheetah Girls Pop Star Sensations | | Multiplayer | |
| Mega Man Star Force 2: Zerker x Ninja | Capcom | Multiplayer | |
| Junior Classic Games | | Multiplayer | |
| Desktop Tower Defense | THQ | Multiplayer | |
| Nancy Drew: The Mystery of the Clue Bender Society | Majesco Entertainment Company | Multiplayer | |
| Again: Interactive Crime Novel | Tecmo Koei | Single Player | |
| Space Invaders Extreme | Square Enix | Multiplayer | |
| Ed, Edd n Eddy: Scam of the Century | D3 Publisher | Multiplayer | |
| Call of Duty 4: Modern Warfare | Activision | Multiplayer | |
| Mega Man Star Force: Leo | Capcom | Single Player | |
| Kids Learn: Math and Spelling Bundle | Talking Stick Games | Single Player | |
| Ragnarok DS | Xseed Games | Multiplayer | |
| Etrian Odyssey II: Heroes of Lagaard | Atlus | Single Player | |
| My SAT Coach with The Princeton Review: Crack the SAT | Ubisoft | Multiplayer | |
| Tenchu: Dark Secret | From Software | Multiplayer | |
| 101-in-1 Explosive Megamix | Atlus | Single Player | |
| Dropcast | THQ | Multiplayer | |
| Hello Kitty: Big City Dreams | Empire Interactive | Multiplayer | |
| Luminous Arc 2 | Atlus | Multiplayer | |
| Heavy Armor Brigade | UFO Interactive Games, Inc. | Multiplayer | |
| Are You Smarter Than a 5th Grader? Back to School | THQ, Inc. | Cooperative; Multiplayer | |
| The Aly and AJ Adventure | | Multiplayer | |
| Florist Shop | UFO Interactive | Single Player | |
| Commando: Steel Disaster | XS Games | Single Player | |
| Neves | Yuke's | Multiplayer | |
| Dig Dug: Digging Strike | Namco | Multiplayer | |
| Indianapolis 500 Legends | | Multiplayer | |
| Puyo Pop Fever | Atlus | Multiplayer | |
| Diner Dash: Flo on the Go | Zoo Games | Single Player | |
| Prince of Persia: The Forgotten Sands | Ubisoft | Single Player | |
| Band Hero | RedOctane | Cooperative; Multiplayer | |
| 100 Classic Books | Nintendo of America Inc. | Multiplayer | |
| Fast Food Panic | SouthPeak Interactive Ltd | Single Player | |
| Don King Boxing | 2K Sports | Multiplayer | |
| Final Fantasy III | Square Enix | Single Player | |
| Marvel Super Hero Squad | THQ | Single Player | |
| My Baby Boy | SouthPeak Games | Single Player | |
| Lost in Blue 2 | Konami | Multiplayer | |
| Chibi-Robo: Park Patrol | Nintendo | Single Player | |
| Legend of Spyro, The: The Eternal Night | Sierra | Single Player | |
| Teenage Zombies: Invasion of the Alien Brain Thingys! | Ignition Entertainment | Single Player | |
| Ferrari Challenge: Trofeo Pirelli | | Multiplayer | |
| Mini RC Rally | | Multiplayer | |
| Roogoo Attack | SouthPeak Games | Multiplayer | |
| Nintendogs: Dalmatian & Friends | Nintendo | Single Player | |
| Moon | Mastiff | Single Player | |
| Imagine: Detective | Ubisoft | Single Player | |
| Goosebumps: HorrorLand | Elastic Media Corporation | Multiplayer | |
| Fantastic Four: Rise of the Silver Surfer | 2K Games | Multiplayer | |
| Exciting Soccer: Konami Cup | Konami | Multiplayer | |
| WWE SmackDown vs Raw 2010 featuring ECW | THQ | Multiplayer | |
| Showtime Championship Boxing | | Multiplayer | |
| Cloudy With a Chance of Meatballs | Ubisoft | Single Player | |
| Chrono Trigger | Square Enix | Multiplayer | |
| Sonny with a Chance | Disney Interactive Studios | Multiplayer | |
| Need for Speed Carbon: Own the City | Electronic Arts | Multiplayer | |
| Glory Days 2 | Secret Stash Games | Multiplayer | |
| Aliens: Infestation | Sega | Single Player | |
| Cory in the House | Disney Interactive Studio | Single Player | |
| Dragon Ball Z: Attack of the Saiyans | Namco Bandai Games | Single Player | |
| Bratz Ponyz | The Game Factory | Multiplayer | |
| Animal Genius | Scholastic | Multiplayer | |
| Custom Robo Arena | Nintendo | Multiplayer | |
| Disney Princess: Magical Jewels | Disney Interactive Studios | Multiplayer | |
| Monsters vs. Aliens | Activision | Multiplayer | |
| Ducati Moto | Vir2L Studios | Multiplayer | |
| Monster Frenzy | | Multiplayer | |
| Imagine: Ice Champions | Ubisoft | Multiplayer | |
| Guitar Rock Tour | | Multiplayer | |
| Hello Kitty: Birthday Adventures | Zoo Digital Publishing | Single Player | |
| Barbie in The 12 Dancing Princesses | Activision | Multiplayer | |
| Red Bull BC One | | Multiplayer | |
| Mah Jong Quest: Expeditions | | Multiplayer | |
| Pokemon Mystery Dungeon: Explorers of Darkness | Nintendo | Single Player | |
| Fab 5 Soccer | | Multiplayer | |
| Battle of Giants: Dragons | Ubisoft | Single Player | |
| Infinite Space | Sega | Single Player | |
| Club Penguin: EPF: Herbert's Revenge | Disney Interactive Studios | Single Player | |
| 101 in 1 Sports Megamix | Atlus | Multiplayer | |
| Grand Theft Auto: Chinatown Wars | Rockstar Games | Single Player | |
| Front Mission 2089: Border of Madness | Square Enix Co., Ltd. | Single Player | |
| Myst | Broderbund | Single Player | |
| Galaxy Racers | | Multiplayer | |
| IL-2 Sturmovik: Birds of Prey | | Multiplayer | |
| Defendin' DePenguin | | Multiplayer | |
| Final Fantasy Fables: Chocobo Tales | Square Enix | Single Player | |
| Fantasy Aquarium by DS | | Multiplayer | |
| Monster Mayhem: Build and Battle | Crave Entertainment | Single Player | |
| Hotel for Dogs | 505 Games | Multiplayer | |
| Kim Possible: Kimmunicator | Buena Vista Games | Single Player | |
| American Dragon: Jake Long: Attack of the Dark Dragon | Disney Interactive Studios | Multiplayer | |
| How to Train Your Dragon | Activision | Multiplayer | |
| Final Fantasy Tactics A2: Grimoire of the Rift | Square Enix | Single Player | |
| Guitar Hero: On Tour | RedOctane | Multiplayer | |
| Emma at the Farm | | Multiplayer | |
| Herbie: Rescue Rally | Disney Interactive Studios | Multiplayer | |
| Chessmaster: The Art of Learning | Ubisoft Entertainment | Multiplayer | |
| Carnival Games | Global Star Software | Multiplayer | |
| The Legend of Zelda: Phantom Hourglass | Nintendo | Multiplayer | |
| Rayman: Raving Rabbids 2 | Ubisoft | Cooperative; Multiplayer | |
| Crime Scene | Southpeak Interactive | Multiplayer | |
| Dementium: The Ward | Gamecock | Single Player | |
| Naruto Shippuden: Ninja Destiny 2 | | Multiplayer | |
| Charm Girls Club: My Fashion Show | Electronic Arts | Multiplayer | |
| Lock's Quest | THQ | Single Player | |
| Elite Forces: Unit 77 | | Multiplayer | |
| Avalon Code | Xseed Games | Single Player | |
| Pokemon Ranger: Shadows of Almia | Nintendo | Single Player | |
| 50 More Classic Games | Destineer | Multiplayer | |
| Hi Hi Puffy AmiYumi: The Genie & the Amp | D3 Publisher | Cooperative; Multiplayer | |
| Hysteria Hospital: Emergency Ward | O-Games | Multiplayer | |
| PDC World Championship Darts | | Multiplayer | |
| River City Soccer Hooligans | Aksys Games | Multiplayer | |
| Cake Mania | Majesco Entertainment | Single Player | |
| Crash of the Titans | Sierra Entertainment | Multiplayer | |
| Dragon Ball Z: Supersonic Warriors 2 | Atari | Multiplayer | |
| CrossworDS | Nintendo | Single Player | |
| Drawn to Life | THQ | Single Player | |
| Eragon | | Multiplayer | |
| Contra 4 | Konami | Cooperative; Multiplayer | |
| Candace Kane's Candy Factory | Destineer | Single Player | |
| Shrek: Smash n' Crash Racing | Activision | Multiplayer | |
| MySims | Electronic Arts | Multiplayer | |
| Call of Duty: Modern Warfare 3: Defiance | Activision | Multiplayer | |
| G.I. Joe: The Rise of Cobra | Electronic Arts | Multiplayer | |
| Rayman: Raving Rabbids | Ubisoft | Single Player | |
| Brain Assist | Sega of America | Multiplayer | |
| Cooking Mama 2: Dinner with Friends | Majesco | Multiplayer | |
| Metroid Prime: Hunters | Nintendo | Multiplayer | |
| Jam Sessions 2 | | Multiplayer | |
| Namco Museum DS | Namco | Multiplayer | |
| Monster Jam: Path of Destruction | Activision | Multiplayer | |
| MySims: Racing | Electronic Arts | Multiplayer | |
| Kim Possible: Global Gemini | Disney Interactive Studios | Single Player | |
| Let's Yoga! | Konami | Multiplayer | |
| LEGO Star Wars II: The Original Trilogy | LucasArts | Single Player | |
| Biker Mice from Mars | The Game Factory | Multiplayer | |
| Jewel Quest: Expeditions | | Single Player | |
| Boogie | Electronic Arts | Multiplayer | |
| Bratz Kidz: Slumber Party | The Game Factory | Multiplayer | |
| Dragon Ball: Origins | Atari | Multiplayer | |
| Ninja Reflex | Nunchuck Games | Multiplayer | |
| Mega Man Star Force 3: Black Ace | Capcom | Multiplayer | |
| Dream Day: Wedding Destinations | THQ | Single Player | |
| Legend of Spyro, The: A New Beginning | Sierra Entertainment | Single Player | |
| Finding Nemo: Escape to the Big Blue: Special Edition | Disney Interactive Studios | Multiplayer | |
| Rainbow Islands: Revolution | Codemasters | Multiplayer | |
| Hannah Montana | DC Studios | Multiplayer | |
| Dragon Quest Monsters: Joker | Square Enix | Multiplayer | |
| Madden NFL 07 | Electronic Arts, Inc. | Multiplayer | |
| WWE SmackDown vs Raw 2008 featuring ECW | THQ | Multiplayer | |
| Dragon Booster | Konami Computer Entertainment | Multiplayer | |
| Bakugan Battle Brawlers: Battle Trainer | Activision, Inc. | Single Player | |
| Dino Master: Dig, Discover, Duel | Majesco Entertainment | Single Player | |
| Ninjatown | South Peak | Single Player | |
| The Backyardigans | 2k Play | Multiplayer | |
| Hotel Dusk: Room 215 | Nintendo | Single Player | |
| Nintendogs: Best Friends | Nintendo | Single Player | |
| Mega Man ZX | Capcom | Single Player | |
| Tecmo Bowl: Kickoff | Tecmo | Multiplayer | |
| Iron Man | Sega | Single Player | |
| Welcome to Animal Crossing: Wild World | Nintendo | Multiplayer | |
| Contact | Atlus | Multiplayer | |
| The Amazing Spider-Man | Activision | Single Player | |
| Ontamarama | Atlus | Multiplayer | |
| Meteos: Disney Magic | Disney Interactive Studios | Multiplayer | |
| Battle of Giants: Dinosaurs | Ubi Soft | Multiplayer | |
| KORG DS-10 Synthesizer | Xseed Games | Single Player | |
| My Hero: Doctor | | Multiplayer | |
| Hi! HamTaro: Ham-Ham Challenge | Natsume | Multiplayer | |
| Meet the Robinsons | Disney Interactive Studios | Multiplayer | |
| Spider-Man 2 | Activision | Multiplayer | |
| Dream Pinball 3D | | Multiplayer | |
| Nintendogs: Chihuahua & Friends | Nintendo | Multiplayer | |
| Magical Starsign | Nintendo | Multiplayer | |
| Johnny Bravo in the Hukka-Mega-Mighty-Ultra-Extreme Date-O-Rama! | | Multiplayer | |
| Hidden Mysteries: Titanic: Secrets of the Fateful Voyage | Activision Value | Multiplayer | |
| Monster Trucks DS | Majesco | Single Player | |
| Madden NFL 2005 | Electronic Arts | Multiplayer | |
| Gunpey DS: Music x Puzzle | Bandai Namco Games | Multiplayer | |
| Nine Hours, Nine Persons, Nine Doors | Aksys Games | Single Player | |
| Mario & Sonic at the Olympic Winter Games | Sega | Multiplayer | |
| Baby Pals | Interchannel | Multiplayer | |
| GoldenEye 007 | Activision | Multiplayer | |
| Final Fantasy IV | Square Enix | Single Player | |
| LostMagic | Ubisoft | Multiplayer | |
| Dora the Explorer: Dora's Big Birthday Adventure | 2K Games | Multiplayer | |
| Henry Hatsworth in the Puzzling Adventure | Electronic Arts | Single Player | |
| Harlem Globetrotters: World Tour | DSI Games | Multiplayer | |
| Texas Hold 'Em Poker DS | Majesco | Single Player | |
| Golden Nugget Casino DS | | Multiplayer | |
| Brothers in Arms DS | Ubisoft | Multiplayer | |
| High School Musical 2: Work This Out! | Disney Interactive Studios, Inc. | Multiplayer | |
| Exit DS | Square Enix | Single Player | |
| Drone Tactics | Atlus | Multiplayer | |
| Garfield's Fun Fest | Destination Software, Inc. | Single Player | |
| Littlest Pet Shop: Country Friends | | Multiplayer | |
| Burger Island | Data Design Interactive | Multiplayer | |
| Garfield's Nightmare | The American Game Factory, Inc. | Multiplayer | |
| Polarium | Nintendo | Multiplayer | |
| Metal Slug 7 | Ignition Entertainment | Multiplayer | |
| New York Times Crosswords | | Multiplayer | |
| Mind Quiz: Your Brain Coach | Sega | Multiplayer | |
| Madagascar: Escape 2 Africa | Activision | Single Player | |
| Mario & Sonic at the Olympic Games | Sega | Multiplayer | |
| EA Playground | Electronic Arts | Multiplayer | |
| Holly Hobbie & Friends | | Multiplayer | |
| Fish Tycoon | Majesco Entertainment Company | Multiplayer | |
| The Chronicles of Narnia: The Lion, the Witch and the Wardrobe | Buena Vista Games | Multiplayer | |
| Frogger: Helmet Chaos | Konami Digital Entertainment, Inc. | Single Player | |
| Cars: Race-O-Rama | THQ | Multiplayer | |
| Disgaea DS | NIS,Atlus | Multiplayer | |
| Atelier Annie: Alchemists of Sera Island | NIS | Single Player | |
| Bust-a-Move DS | Majesco | Multiplayer | |
| Imagine: Artist | Ubisoft | Multiplayer | |
| Astro Boy: The Video Game | D3 Publisher | Cooperative; Multiplayer | |
| Battles of Prince of Persia | Ubisoft | Single Player | |
| Arkanoid DS | Taito | Single Player | |
| Charm Girls Club: My Fashion Mall | Electronic Arts | Multiplayer | |
| Bangai-O Spirits | D3 Publisher | Multiplayer | |
| Fullmetal Alchemist: Dual Sympathy | Bandai | Single Player | |
| The Legend of Kage 2 | Taito | Single Player | |
| My World, My Way | Atlus | Single Player | |
| Backyard Football '09 | Atari, Inc. | Multiplayer | |
| FIFA Soccer 06 | EA Sports | Multiplayer | |
| Big Bang Mini | SouthPeak Games | Multiplayer | |
| N+ | Atari | Multiplayer | |
| Dancing with the Stars: We Dance! | Activision Publishing | Multiplayer | |
| Miami Nights: Singles in the City | Ubisoft | Multiplayer | |
| Zoo Keeper | Ignition Entertainment | Multiplayer | |
| Cocoto Kart Racer | Conspiracy Entertainment | Multiplayer | |
| Izuna 2: The Unemployed Ninja Returns | Atlus | Single Player | |
| Brain Quest: Grades 5 & 6 | Electronic Arts | Multiplayer | |
| Emergency Room: Real Life Rescues | Legacy Interactive Inc. | Multiplayer | |
| Drivers Ed Portable | DreamCatcher Interactive | Single Player | |
| Hello Kitty: Daily | Dorasu | Multiplayer | |
| I Love Beauty: Hollywood Makeover | | Multiplayer | |
| My Pet Chimp | | Multiplayer | |
| Konductra | O~3 Entertainment | Multiplayer | |
| Dragon Quest 5: Hand of the Heavenly Bride | Square Enix | Multiplayer | |
| Monster Racers | | Multiplayer | |
| Bleach: Dark Souls | Sega | Multiplayer | |
| Freedom Wings | Natsume | Multiplayer | |
| Rayman: Raving Rabbids: TV Party | | Multiplayer | |
| Boing! Docomodake DS | Ignition Entertainment | Single Player | |
| Math Blaster in the Prime Adventure | Majesco | Single Player | |
| Fossil Fighters: Champions | Nintendo | Multiplayer | |
| Miss Spider's Sunny Patch Friends: Harvest Time Hop and Fly | The Game Factory | Multiplayer | |
| TMNT | Ubisoft | Multiplayer | |
| Daniel X: The Ultimate Power | THQ Inc. | Multiplayer | |
| Hasbro Family Game Night | | Multiplayer | |
| Drawn to Life: SpongeBob SquarePants Edition | Play THQ | Single Player | |
| Madagascar Kartz | Activision | Multiplayer | |
| Robocalypse | Tecmo | Cooperative; Multiplayer | |
| Etrian Odyssey III: The Drowned City | Atlus | Single Player | |
| Imagine: Figure Skater | | Multiplayer | |
| AMF Bowling Pinbusters! | Vir2L Studios Inc. | Multiplayer | |
| Tamagotchi Connection: Corner Shop 3 | Namco Bandai Games | Multiplayer | |
| Beat City | THQ | Single Player | |
| Margot's Word Brain | ZOO Digital Publishing Ltd | Single Player | |
| Dragon Ball: Origins 2 | Namco Bandai Games | Multiplayer | |
| Imagine: Fashion Designer | Ubisoft | Single Player | |
| New Zealand Story Revolution | Ignition Entertainment | Single Player | |
| That's So Raven: Psychic on the Scene | Buena Vista Games | Multiplayer | |
| Madden NFL 06 | Electronic Arts | Multiplayer | |
| Mega Man Zero Collection | Capcom | Single Player | |
| The Mummy: Tomb of the Dragon Emperor | Sierra Entertainment | Multiplayer | |
| Littlest Pet Shop: Jungle | | Multiplayer | |
| Curling DS | Rocket Company | Multiplayer | |
| Dawn of Heroes | Majesco | Multiplayer | |
| Flipper Critters | Ignition Entertainment | Single Player | |
| Emma in the Mountains | | Multiplayer | |
| Rondo of Swords | Atlus | Single Player | |
| Dynasty Warriors DS: Fighter's Battle | Koei | Multiplayer | |
| Digimon World Championship | Namco Bandai Games | Multiplayer | |
| Little Mermaid, The: Ariel's Undersea Adventure | Buena Vista Games | Single Player | |
| I Love Horses | | Multiplayer | |
| Big Brain Academy | Nintendo | Multiplayer | |
| Indiana Jones and the Staff of Kings | LucasArts | Single Player | |
| Legacy of Ys: Books I & II | Atlus | Multiplayer | |
| Arctic Tale | Destination Software | Multiplayer | |
| Shin Megami Tensei: Strange Journey | Atlus | Single Player | |
| The Chase: Felix Meets Felicity | | Multiplayer | |
| Asphalt: Urban GT | Ubisoft | Multiplayer | |
| Inuyasha: Secret of the Divine Jewel | Namco Bandai Games America Inc. | Single Player | |
| Ghost Trick: Phantom Detective | Capcom | Single Player | |
| 4 Game Fun Pack: Monopoly + Boggle + Yahtzee + Battleship | Atari | Multiplayer | |
| Guitar Hero: On Tour: Modern Hits | Activision | Multiplayer | |
| Backyard Hockey | Atari | Multiplayer | |
| Luxor: Pharaoh's Challenge | MumboJumbo | Single Player | |
| Cars: Mater-National Championship | THQ | Multiplayer | |
| Jackass: The Game DS | Red Mile Entertainment, Inc. | Multiplayer | |
| Charlotte's Web | SEGA of America, Inc. | Single Player | |
| Nursery Mania | | Multiplayer | |
| Rafa Nadal Tennis | Codemasters | Multiplayer | |
| Let's Pilates! | Konami Digital Entertainment | Multiplayer | |
| MySims Party | Electronic Arts | Multiplayer | |
| Call of Duty: Black Ops | Activision | Single Player | |
| Nancy Drew: The Model Mysteries | | Multiplayer | |
| Marvel Trading Card Game | Konami | Multiplayer | |
| Dungeon Raiders | UFO Interactive | Single Player | |
| Mr. Driller: Drill Spirits | Namco | Single Player | |
| Littlest Pet Shop: City Friends | | Multiplayer | |
| Shrek: SuperSlam | Activision | Multiplayer | |
| The Rub Rabbits! | Sega | Multiplayer | |
| Electroplankton | Nintendo | Single Player | |
| Backyard Basketball | Atari | Multiplayer | |
| Puzzle Chronicles | Konami | Multiplayer | |
| CSI: Crime Scene Investigation: Unsolved! | Ubisoft | Single Player | |
| March of the Penguins | Destination Software Inc (DSI) | Multiplayer | |
| Ninja Gaiden: Dragon Sword | Tecmo | Single Player | |
| Hannah Montana: Music Jam | | Multiplayer | |
| Star Wars: Episode III: Revenge of the Sith | Ubisoft | Multiplayer | |
| Build-a-lot | MumboJumbo | Single Player | |
| Best of Tests DS | Conspiracy Entertainment | Multiplayer | |
| Cooking Mama | Majesco | Multiplayer | |
| Midnight Play! Pack | | Multiplayer | |
| QuickSpot | Namco Bandai | Single Player | |
| Insecticide | | Multiplayer | |
| Call of Duty: Modern Warfare: Mobilized | Activision | Multiplayer | |
| Major League Baseball 2K8: Fantasy All-Stars | 2K Sports | Multiplayer | |
| SpongeBob SquarePants: Plankton's Robotic Revenge | Activision | Multiplayer | |
| Uno / Skip-Bo / Uno Freefall | DSI Games | Single Player | |
| LEGO Star Wars: The Complete Saga | LucasArts | Multiplayer | |
| Animal Paradise | Empire Interactive | Single Player | |
| Jillian Michaels Fitness Ultimatum 2010 | Majesco | Multiplayer | |
| Jonas | Disney Interactive Studios | Multiplayer | |
| Peter Jackson's King Kong: The Official Game of the Movie | Ubisoft | Multiplayer | |
| Lost in Blue | Konami | Single Player | |
| Alice in Wonderland | Disney Interactive Studios | Single Player | |
| Robots | Sierra | Single Player | |
| Need for Speed: Nitro | Electronic Arts | Multiplayer | |
| Real Time Conflict: Shogun Empires | | Multiplayer | |
| Ultimate Mortal Kombat | Midway | Multiplayer | |
| Backyard Baseball '09 | Atari | Multiplayer | |
| Nintendogs: Dachshund & Friends | Nintendo | Multiplayer | |
| Pac-Man World 3 | Namco | Single Player | |
| Nicktoons: Attack of the Toybots | THQ | Single Player | |
| Children of Mana | Nintendo | Multiplayer | |
| GoPets: Vacation Island! | | Multiplayer | |
| Little League World Series Baseball 2009 | Activision | Multiplayer | |
| Mario Party DS | Nintendo | Multiplayer | |
| Dora the Explorer: Dora Saves the Snow Princess | 2k Play | Single Player | |
| The Quest Trio: Jewels, Cards and Tiles | | Multiplayer | |
| Space Invaders Extreme 2 | Square Enix | Single Player | |
| 7 Wonders of the Ancient World | Mumbo Jumbo | Single Player | |
| Animal Boxing | Destineer | Multiplayer | |
| Just in Time Translations: Say It in 6 Languages | | Multiplayer | |
| American Girl: Kit Mystery Challenge! | THQ Inc. | Single Player | |
| Over the Hedge: Hammy Goes Nuts! | Activision | Multiplayer | |
| Pokemon Mystery Dungeon: Explorers of Sky | Nintendo | Multiplayer | |
| Jambo! Safari: Animal Rescue | | Multiplayer | |
| Charm Girls Club: My Perfect Prom | Electronic Arts | Multiplayer | |
| Backyard Sports: Sandlot Sluggers | Atari | Single Player | |
| Homie Rollerz | Destineer | Multiplayer | |
| Dodge Racing: Charger vs Challenger | | Multiplayer | |
| Golden Sun: Dark Dawn | Nintendo | Single Player | |
| Interactive Storybook DS: Series 1 | | Multiplayer | |
| Bubble Bobble: Double Shot | Ignition Entertainment | Multiplayer | |
| Mega Brain Boost | | Multiplayer | |
| Go, Diego, Go! Great Dinosaur Rescue | 2k Play | Single Player | |
| Shamu's Deep Sea Adventures | Activision | Multiplayer | |
| Broken Sword: Shadow of the Templars: The Director's Cut | Ubisoft | Single Player | |
| Astro Invaders | Zoo Publishing | Multiplayer | |
| James Cameron's Avatar: The Game | Ubisoft | Multiplayer | |
| Sonic & SEGA All-Stars Racing | Sega | Multiplayer | |
| Danny Phantom: Urban Jungle | THQ | Multiplayer | |
| Monster Jam | Activision | Multiplayer | |
| Ant Nation | Konami | Multiplayer | |
| Kamen Rider: Dragon Knight | D3Publisher | Multiplayer | |
| Teenage Mutant Ninja Turtles 3: Mutant Nightmare | Konami | Multiplayer | |
| Pimp My Ride: Street Racing | | Multiplayer | |
| Guitar Hero: On Tour: Decades | Activision | Single Player | |
| Lux-Pain | Ignition Entertainment | Multiplayer | |
| WWE SmackDown vs Raw 2009 featuring ECW | THQ | Single Player | |
| Cars | THQ | Multiplayer | |
| Iron Chef America: Supreme Cuisine | Destineer | Multiplayer | |
| The Hardy Boys: Treasure on the Tracks | Sega of America | Single Player | |
| Mystery Dungeon: Shiren the Wanderer | Sega | Single Player | |
| Dragon Ball Z: Harukanaru Densetsu | Atari | Multiplayer | |
| DiRT 2 | Codemasters | Multiplayer | |
| Impossible Mission | Warner Bros. Interactive | Single Player | |
| Alvin and the Chipmunks | Brash entertainment | Single Player | |
| Lionel Trains: On Track | DSI Games | Single Player | |
| SpongeBob SquarePants: Creature from the Krusty Krab | THQ | Single Player | |
| Resident Evil: Deadly Silence | Capcom | Multiplayer | |
| Phoenix Wright: Ace Attorney: Trials and Tribulations | Capcom | Single Player | |
| Brain Quest Grades 3 & 4 | Electronic Arts | Multiplayer | |
| My Boyfriend | | Multiplayer | |
| Franklin's Great Adventures | The American Game Factory | Multiplayer | |
| Jewel Master: Cradle of Rome 2 | Rising Star | Single Player | |
| Hero's Saga: Laevatein Tactics | Aksys Games | Multiplayer | |
| Konami Classics Series: Arcade Hits | Konami Corporation | Multiplayer | |
| Mario vs. Donkey Kong 2: March of the Minis | Nintendo | Single Player | |
| Crash: Mind Over Mutant | Activision Blizzard | Multiplayer | |
| Bionicle Heroes | Eidos Interactive | Multiplayer | |
| Dogz 2 | Ubisoft, Inc. | Single Player | |
| Yoshi's Island DS | Nintendo | Single Player | |
| My Secret World by Imagine | Ubisoft | Multiplayer | |
| Might & Magic: Clash of Heroes | Ubisoft | Multiplayer | |
| Age of Empires: The Age of Kings | Majesco | Multiplayer | |
| Tetris Party Deluxe | Majesco Games | Multiplayer | |
| Happy Cooking | Ubisoft | Multiplayer | |
| From the Abyss | Aksys Games Localization, Inc. | Multiplayer | |
| Heroes of Mana | Square Enix | Single Player | |
| Hot Wheels: Beat That! | Activision | Multiplayer | |
| Chicken Shoot | | Multiplayer | |
| Despicable Me: The Game: Minion Mayhem | D3Publisher | Single Player | |
| MX vs. ATV Reflex | THQ Inc. | Multiplayer | |
| Fighting Fantasy: The Warlock of Firetop Mountain | Aspyr | Single Player | |
| Race Driver: Create & Race | The Codemasters Software Company Limited | Multiplayer | |
| MySims Agents | Electronic Arts | Single Player | |
| Amazing Adventures: The Forgotten Ruins | PopCap Games | Single Player | |
| The Golden Compass | SEGA of America, Inc. | Multiplayer | |
| LEGO Battles | Warner Bros | Single Player | |
| Mage Knight: Destiny's Soldier | Namco Bandai | Single Player | |
| Age of Empires: Mythologies | THQ | Multiplayer | |
| Scribblenauts Collection | Warner Bros Interactive | Single Player | |
| B-17: Fortress in the Sky | DSI Games | Multiplayer | |
| Fabulous Finds | THQ | Multiplayer | |
| Phoenix Wright: Ace Attorney | Capcom | Single Player | |
| New International Track & Field | Konami | Multiplayer | |
| 4 Game Pack!: Clue Aggravation Perfection Mouse Trap | | Multiplayer | |
| Crayola Treasure Adventures | Crave Entertainment | Single Player | |
| My Dress-Up | | Multiplayer | |
| CSI: Crime Scene Investigation: Deadly Intent: The Hidden Cases | Ubisoft | Single Player | |
| Pipe Mania | Empire Interactive | Single Player | |
| Madagascar | Activision | Multiplayer | |
| Left Brain, Right Brain 2 | Majesco | Multiplayer | |
| Chuck E. Cheese's Party Games | UFO Interactive | Multiplayer | |
| Happy Feet | Midway | Multiplayer | |
| Jenga World Tour | | Multiplayer | |
| Bakugan: Battle Brawlers | Activision | Multiplayer | |
| Jagged Alliance | Empire Interactive | Multiplayer | |
| Bleach: The 3rd Phantom | Sega | Multiplayer | |
| Mario & Luigi: Bowser's Inside Story | Nintendo | Single Player | |
| Pokemon Ranger: Shadows of Almia | Nintendo | Single Player | |
| Orcs & Elves | Electronic Arts | Single Player | |
| Metroid Prime Pinball | Nintendo | Single Player | |
| Neopets Puzzle Adventure | Capcom | Multiplayer | |
| Let's Play: Flight Attendant | Deep Silver | Multiplayer | |
| The Biggest Loser | THQ Inc. | Single Player | |
| Guilty Gear: Dust Strikers | Majesco | Multiplayer | |
| Rayman DS | Ubisoft | Single Player | |
| Knights in the Nightmare | Atlus | Single Player | |
| Animal Planet: Emergency Vets | Activision | Single Player | |
| Hot Wheels: Battle Force 5 | Activision Publishing, Inc. | Multiplayer | |
| Digimon World DS | Namco Bandai Games | Multiplayer | |
| Alex Rider: Stormbreaker | THQ | Single Player | |
| Imagine: Makeup Artist | Ubisoft | Multiplayer | |
| Need for Speed: Underground 2 | Electronic Arts | Multiplayer | |
| KORG DS-10 Synthesizer | Xseed Games | Single Player | |
| Call of Duty: World at War | Activision | Multiplayer | |
| Mystery Case Files: MillionHeir | Nintendo | Multiplayer | |
| Balloon Pop | UFO Interactive | Single Player | |
| Nancy Drew: The Deadly Secret of Olde World Park | Majesco Entertainment | Single Player | |
| Mario vs. Donkey Kong: Mini-Land Mayhem | Nintendo | Single Player | |
| Kung Fu Panda | Activision | Single Player | |
| Open Season | Ubisoft | Multiplayer | |
| Fantasy Aquarium by DS | | Multiplayer | |
| Need for Speed: Undercover | Electronic Arts | Single Player | |
| Fire Emblem: Shadow Dragon | Nintendo | Multiplayer | |
| LEGO Harry Potter: Years 1-4 | Warner Bros. Interactive Entertainment Inc. | Cooperative; Multiplayer | |
| Cake Mania: Main Street | | Multiplayer | |
| American Girl: Julie Finds a Way | THQ | Multiplayer | |
| Final Fantasy: The 4 Heroes of Light | Square-Enix | Single Player | |
| Looney Tunes: Duck Amuck | WB Games | Multiplayer | |
| Bomberman Land Touch! 2 | Hudson Soft | Multiplayer | |
| Little League World Series Baseball: Double Play | Activision | Multiplayer | |
| Scooby-Doo!: Unmasked | THQ | Single Player | |
| FIFA Soccer 08 | Electronic Arts | Multiplayer | |
| ATV: Wild Ride | Destineer | Multiplayer | |
| Mechanic Master | Midway Games | Multiplayer | |
| Ni Hao, Kai-Lan: New Year's Celebration | 2k Play | Multiplayer | |
| Let's Draw! | Majesco | Multiplayer | |
| Harvest Moon DS: Island of Happiness | Natsume | Single Player | |
| Kingdom Hearts 358/2 Days | Square Enix | Multiplayer | |
| Flower, Sun, and Rain: The Endless Park | Marvelous | Single Player | |
| Grey's Anatomy: The Video Game | Ubisoft | Multiplayer | |
| 007: Blood Stone | Activision Publishing, Inc. | Multiplayer | |
| Pokemon Mystery Dungeon: Explorers of Time | Nintendo | Single Player | |
| Double Sequence: The Q-Virus Invasion | | Multiplayer | |
| Need for Speed: Most Wanted | Electronic Arts | Multiplayer | |
| Puzzle Quest 2 | D3 Publisher | Multiplayer | |
| Betty Boop's Double Shift | DSI Games | Multiplayer | |
| Fullmetal Alchemist: Trading Card Game | Destineer | Multiplayer | |
| Mega Man Star Force 2: Zerker x Saurian | Capcom | Single Player | |
| Chicken Little: Ace in Action | Buena Vista Games, Inc. | Multiplayer | |
| Agatha Christie: The ABC Murders | The Adventure Company | Single Player | |
| 2 Game Pack!: Monster Trucks Mayhem and ATV: Thunder Ridge Riders | Destination Software | Multiplayer | |
| Rune Factory 2: A Fantasy Harvest Moon | Natsume | Single Player | |
| Puppy Luv: Spa and Resort | Activision | Multiplayer | |
| Monster House | THQ | Single Player | |
| Black Sigil: Blade of the Exiled | Graffiti Entertainment | Single Player | |
| Crash Boom Bang! | Sierra Entertainment | Multiplayer | |
| Bomberman | Ubisoft | Multiplayer | |
| Command and Destroy | Destination Software | Multiplayer | |
| Pokemon Dash | Nintendo | Multiplayer | |
| Enchanted | Disney Interactive Studios | Multiplayer | |
| Backyard Baseball '10 | Atari | Multiplayer | |
| Our House | Majesco Entertainment | Single Player | |
| Ratatouille | THQ | Single Player | |
| Harvest Moon DS: Cute | Natsume / Marvelous Entertainment | Single Player | |
| Interactive Storybook DS: Series 2 | | Multiplayer | |
| Ace Attorney Investigations: Miles Edgeworth | Capcom | Single Player | |
| LEGO Indiana Jones: The Original Adventures | LucasArts | Cooperative; Multiplayer | |
| Major League Baseball 2K7 | 2K Sports | Multiplayer | |
| Drama Queens | | Multiplayer | |
| Monster Rancher DS | UFO Interactive | Multiplayer | |
| Geometry Wars: Galaxies | Sierra Entertainment | Cooperative; Multiplayer | |
| 1 vs. 100 | Destination Software, Inc. (DSI) | Multiplayer | |
| Harvest Moon: Frantic Farming | Natsume | Cooperative; Multiplayer | |
| Away: Shuffle Dungeon | Majesco | Multiplayer | |
| Legend of Spyro, The: Dawn of the Dragon | Sierra Entertainment / Activision Blizzard | Single Player | |
| Build-A-Bear Workshop: Welcome to Hugsville | | Multiplayer | |
| thinkSMART: Labyrinth | Mentor Interactive Inc. | Multiplayer | |
| Marker Man Adventures | Majesco | Single Player | |
| Disney: Stitch Jam | Disney Interactive Studios | Single Player | |